OCT-Angiography and Adaptive Optics in Patients With Memory Impairment

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI : amnestic mild cognitive impairment), or to other neurodegenerative diseases such as frontotemporal dementia or Lewy body diseases. These retinal anomalies objectified by OCT-A (Optical coherence tomography angiography) and adaptive optics (AO) appear different depending on the pathologies and could therefore serve as markers in vivo of the pathophysiological processes underlying NCD. No study to date has studied the retina and its vessels in NCD using adaptive optics. In this pilot study, we are proposing a combination of two new ophthalmological imaging techniques (OCT-A and AO), which allow rapid in vivo analysis in a completely non-invasive way of the morphology of small vessels as well as architecture of the retina to better specify the retinal anomalies associated with NCD. We will compare the parameters in OCT-A and AO between patients with NCD and controls without NCD (with memory complaint or without) and will seek to determine if there are different profiles according to the causes of NCD.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Patient presenting in memory consultation for memory complaint or person accompanying a patient in memory consultation for memory complaint

Locations
Other Locations
France
Hôpital Fondation A. de Rothschild
RECRUITING
Paris
Contact Information
Primary
Amélie YACHITZ, MD
ayavchitz@for.paris
(0)148036454
Backup
Antoine MOULIGNIER, MD
amoulignier@for.paris
Time Frame
Start Date: 2020-06-26
Estimated Completion Date: 2026-06
Participants
Target number of participants: 450
Treatments
Experimental: NCD patients (case)
Patient diagnosed with Alzheimer's disease or parkinsonian dementia / Lewy body dementia or other mild or severe NCD defined by international criteria.
Other: Control patients with memory complaint
Normal neuropsychological evaluation during assessment
Other: Control patients without memory complaint
MMS score and / or the Montreal Cognitive Assessment grid (MoCA) ≥26 / 30, No memory complaint
Sponsors
Leads: Fondation Ophtalmologique Adolphe de Rothschild

This content was sourced from clinicaltrials.gov